{"id":169,"date":"2021-06-30T14:19:51","date_gmt":"2021-06-30T14:19:51","guid":{"rendered":"https:\/\/mims.parabolasolution.com\/?page_id=169"},"modified":"2026-04-01T14:51:12","modified_gmt":"2026-04-01T06:51:12","slug":"instructions-for-infusion","status":"publish","type":"page","link":"https:\/\/bms.mimsit.net\/dosing\/1l-metastatic-recurrent-nsclc-with-chemo\/instructions-for-infusion\/","title":{"rendered":"Instructions for infusion"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"169\" class=\"elementor elementor-169\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-332d7205 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"332d7205\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-37201b2d\" data-id=\"37201b2d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16072a07 elementor-widget elementor-widget-text-editor\" data-id=\"16072a07\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<table class=\"table table-border table-sm table-infusion\">\n<thead>\n<tr>\n<th class=\"w-25\"><\/th>\n<th class=\"w-25 text-center\">Nivolumab<\/th>\n<th class=\"w-25 text-center\">Ipilimumab<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"table-infusion-row1\">\n<td class=\"align-middle p-3\">\n<div class=\"d-none d-lg-block\"><img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_iv.png\" width=\"70px\" \/> <span class=\"table-infusion-th\">Reconstitution<\/span><\/div>\n<div class=\"d-block d-lg-none\">\n\n<img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_iv.png\" width=\"70px\" \/>\n<p class=\"table-infusion-th\">Reconstitution<\/p>\n\n<\/div><\/td>\n<td class=\"align-middle\" colspan=\"2\">Dilute the required volume of nivolumab or ipilimumab with the required volume of 0.9% sodium chloride solution or 5% glucose solution for injection<sup>1<\/sup><\/td>\n<\/tr>\n<tr class=\"table-infusion-row2\">\n<td class=\"align-middle p-3\">\n<div class=\"d-none d-lg-block\"><img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_notepad.png\" width=\"70px\" \/> <span class=\"table-infusion-th\">Duration of infusion<\/span><\/div>\n<div class=\"d-block d-lg-none\">\n\n<img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_notepad.png\" width=\"70px\" \/>\n<p class=\"table-infusion-th\">Duration of infusion<\/p>\n\n<\/div><\/td>\n<td class=\"text-center align-middle\">30-min IV infusion<sup>1<\/sup><\/td>\n<td class=\"text-center align-middle\">30-min IV infusion<sup>2<\/sup><\/td>\n<\/tr>\n<tr class=\"table-infusion-row1\">\n<td class=\"align-middle p-3\">\n<div class=\"d-none d-lg-block\"><img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_timer.png\" width=\"70px\" \/> <span class=\"table-infusion-th\">Order of infusion<\/span><\/div>\n<div class=\"d-block d-lg-none\">\n\n<img decoding=\"async\" src=\"\/dosing\/wp-content\/uploads\/2021\/06\/icon_b_timer.png\" width=\"70px\" \/>\n<p class=\"table-infusion-th\">Order of infusion<\/p>\n\n<\/div><\/td>\n<td class=\"align-middle\" colspan=\"2\">For combination therapy, nivolumab and ipilimumab should be administered on the same day.<sup>1<\/sup>\u00a0Nivolumab infusion should be followed by ipilimumab infusion in all indications where combination therapy is indicated.<sup>1<\/sup> Administer nivolumab first, followed by the other therapeutic agent(s).<sup>1<\/sup><br>1L only: For the monotherapy phase, the first dose of nivolumab should be administered 3 weeks after the last dose of the combination of nivolumab and ipilumab if using 240 mg every 2 weeks or 480 mg every 4 weeks<sup>1<\/sup><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc599ad elementor-widget elementor-widget-text-editor\" data-id=\"cc599ad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tIV, intravenous.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-491e3d1 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"491e3d1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b61491c\" data-id=\"b61491c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b42e5dc elementor-widget elementor-widget-text-editor\" data-id=\"b42e5dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>1. Opdivo<sup>\u00ae<\/sup> (nivolumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.\u00a0<br \/>2. Yervoy<sup>\u00ae<\/sup> (ipilimumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c6358a7\" data-id=\"c6358a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6cdd37 elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"a6cdd37\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png 225w, https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026-150x150.png 150w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6a0761 elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"c6a0761\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"144\" height=\"144\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-yervoy-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Nivolumab Ipilimumab Reconstitution Reconstitution Dilute the required volume of nivolumab or ipilimumab with the required volume of 0.9% sodium chloride solution or 5% glucose solution for injection1 Duration of infusion Duration of infusion 30-min IV infusion1 30-min IV infusion2 Order of infusion Order of infusion For combination therapy, nivolumab and ipilimumab should be administered on [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":161,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"page-template2.php","meta":{"footnotes":""},"class_list":["post-169","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/comments?post=169"}],"version-history":[{"count":80,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/169\/revisions"}],"predecessor-version":[{"id":1776,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/169\/revisions\/1776"}],"up":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/161"}],"wp:attachment":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/media?parent=169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}