{"id":213,"date":"2021-06-30T15:02:03","date_gmt":"2021-06-30T15:02:03","guid":{"rendered":"https:\/\/mims.parabolasolution.com\/?page_id=213"},"modified":"2026-04-01T14:42:16","modified_gmt":"2026-04-01T06:42:16","slug":"1l-advanced-hcc","status":"publish","type":"page","link":"https:\/\/bms.mimsit.net\/dosing\/1l-advanced-hcc\/","title":{"rendered":"1L+ advanced HCC"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"213\" class=\"elementor elementor-213\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-16d74b02 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"16d74b02\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1082ed1b\" data-id=\"1082ed1b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50c54087 elementor-widget elementor-widget-text-editor\" data-id=\"50c54087\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<figure class=\"wp-block-image size-full img-fluid\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1204 size-full\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/1l-advanced-hcc-fig-1-mar-9-scaled.png\" alt=\"\" width=\"1729\" height=\"743\" \/><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:html -->\n<p><a class=\"foobox text-dark d-block d-lg-none\" href=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/1l-advanced-hcc-fig-1-mar-9-scaled.png\"> <img decoding=\"async\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2021\/07\/btn_zoom_m.png\" width=\"30px\" \/> Click to zoom <\/a><\/p>\n<!-- \/wp:html -->\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-524767e elementor-widget elementor-widget-text-editor\" data-id=\"524767e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>*1L+: After completing a maximum of 4 doses of combination therapy, administer nivolumab as a single agent until disease progression, unacceptable toxicity, or up to two years.<sub style=\"top: -.5em;\">1<\/sub><\/p>\n<p>1L only: For the monotherapy phase, the first dose of nivolumab should be administered 3 weeks after the last dose of the combination of nivolumab and ipilumab if using 240 mg every 2 weeks or 480 mg every 4 weeks.<sub style=\"top: -.5em;\">1<\/sub><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ff333eb elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ff333eb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-034393b\" data-id=\"034393b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8dc117c elementor-widget elementor-widget-text-editor\" data-id=\"8dc117c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>1L+, first line or later; HCC, hepatocellular carcinoma; IV, intravenous; QxW, every x weeks.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f00acc elementor-widget elementor-widget-text-editor\" data-id=\"9f00acc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>1. Opdivo<sup>\u00ae<\/sup> (nivolumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.<br \/>2. Yervoy<sup>\u00ae<\/sup> (ipilimumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9ec6d1a\" data-id=\"9ec6d1a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3351bdd elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"3351bdd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png 225w, https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026-150x150.png 150w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c40972d elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"c40972d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"144\" height=\"144\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-yervoy-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Click to zoom *1L+: After completing a maximum of 4 doses of combination therapy, administer nivolumab as a single agent until disease progression, unacceptable toxicity, or up to two years.1 1L only: For the monotherapy phase, the first dose of nivolumab should be administered 3 weeks after the last dose of the combination of nivolumab [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":77,"parent":0,"menu_order":50,"comment_status":"closed","ping_status":"closed","template":"page-template1.php","meta":{"footnotes":""},"class_list":["post-213","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/comments?post=213"}],"version-history":[{"count":60,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/213\/revisions"}],"predecessor-version":[{"id":1756,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/213\/revisions\/1756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/media\/77"}],"wp:attachment":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/media?parent=213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}