{"id":231,"date":"2021-06-30T15:12:15","date_gmt":"2021-06-30T15:12:15","guid":{"rendered":"https:\/\/mims.parabolasolution.com\/?page_id=231"},"modified":"2026-05-08T09:22:28","modified_gmt":"2026-05-08T01:22:28","slug":"1l-msi-h-d-mmr-metastatic-recurrent-crc","status":"publish","type":"page","link":"https:\/\/bms.mimsit.net\/dosing\/1l-msi-h-d-mmr-metastatic-recurrent-crc\/","title":{"rendered":"1L+ MSI-H\/d-MMR metastatic\/recurrent CRC"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"231\" class=\"elementor elementor-231\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5dda3cae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5dda3cae\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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.elementor-tabs-wrapper{-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tabs-content-wrapper{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1;border-style:solid solid solid none}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-content{border-style:none solid solid}.elementor-widget-tabs.elementor-tabs-alignment-center .elementor-tabs-wrapper,.elementor-widget-tabs.elementor-tabs-alignment-end .elementor-tabs-wrapper,.elementor-widget-tabs.elementor-tabs-alignment-stretch .elementor-tabs-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-tabs.elementor-tabs-alignment-center .elementor-tabs-wrapper{-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center}.elementor-widget-tabs.elementor-tabs-alignment-end .elementor-tabs-wrapper{-webkit-box-pack:end;-ms-flex-pack:end;justify-content:flex-end}.elementor-widget-tabs.elementor-tabs-alignment-stretch.elementor-tabs-view-horizontal .elementor-tab-title{width:100%}.elementor-widget-tabs.elementor-tabs-alignment-stretch.elementor-tabs-view-vertical .elementor-tab-title{height:100%}.elementor-tabs .elementor-tab-mobile-title{display:none}}<\/style>\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1331\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-1331\" aria-expanded=\"false\">1L setting<sup>1<\/sup><\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1332\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1332\" aria-expanded=\"false\">2L+ setting<sup>2<\/sup><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-1331\" aria-expanded=\"false\">1L setting<sup>1<\/sup><\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1331\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1331\" tabindex=\"0\" hidden=\"false\"><figure class=\"wp-block-image size-full img-fluid\"><a class=\"foobox\" href=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/1l-msi-h-d-mmr-metastatic-recurrent-crc-fig-1-mar-9-v2.png\"><img decoding=\"async\" class=\"wp-image-237\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/05\/1l-msi-h-d-mmr-metastatic-recurrent-crc-fig-1-mar-9-v3.png\" alt=\"\" \/><\/a><\/figure>\n<a class=\"foobox text-dark d-block d-lg-none\" href=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/05\/1l-msi-h-d-mmr-metastatic-recurrent-crc-fig-1-mar-9-v3.png\"> <img decoding=\"async\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2021\/07\/btn_zoom_m.png\" width=\"30px\" \/> Click to zoom <\/a><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1332\" aria-expanded=\"false\">2L+ setting<sup>2<\/sup><\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1332\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1332\" tabindex=\"0\" hidden=\"hidden\"><figure class=\"wp-block-image size-full img-fluid\"><a class=\"foobox\" href=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/crc-2l-setting.png\"><img decoding=\"async\" class=\"wp-image-237\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/crc-2l-setting.png\" alt=\"\" \/><\/a><\/figure>\n<a class=\"foobox text-dark d-block d-lg-none\" href=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/03\/crc-2l-setting.png\"> <img decoding=\"async\" src=\"http:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2021\/07\/btn_zoom_m.png\" width=\"30px\" \/> Click to zoom <\/a><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4582a1 elementor-widget elementor-widget-text-editor\" data-id=\"f4582a1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>*In all settings, nivolumab monotherapy should be initiated 3 weeks following the last dose of the combination of nivolumab and ipilimumab.<sup>1<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d58f659 elementor-widget elementor-widget-text-editor\" data-id=\"d58f659\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>1L, first-line; 1L+, first-line or later; 2L+, second-line or later; CRC, colorectal cancer; d-MMR, mismatch repair deficient; IV, intravenous; MSI-H, high microsatellite instability; QxW, every x weeks.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-34f3383 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"34f3383\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-669829a\" data-id=\"669829a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0a6a4a elementor-widget elementor-widget-text-editor\" data-id=\"e0a6a4a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>1. Opdivo<sup>\u00ae<\/sup> (nivolumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.\u00a0<br \/>2. Yervoy<sup>\u00ae<\/sup> (ipilimumab). Hong Kong Prescribing Information; Hong Kong: Bristol-Myers Squibb.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e108f4b\" data-id=\"e108f4b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c24334 elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"1c24334\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.5 - 03-02-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026.png 225w, https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-opdivo-feb-27-2026-150x150.png 150w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c7c9ab elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"9c7c9ab\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"144\" height=\"144\" src=\"https:\/\/bms.mimsit.net\/dosing\/wp-content\/uploads\/2026\/02\/qr-yervoy-feb-27-2026.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>1L setting1 2L+ setting2 1L setting1 Click to zoom 2L+ setting2 Click to zoom *In all settings, nivolumab monotherapy should be initiated 3 weeks following the last dose of the combination of nivolumab and ipilimumab.1 1L, first-line; 1L+, first-line or later; 2L+, second-line or later; CRC, colorectal cancer; d-MMR, mismatch repair deficient; IV, intravenous; MSI-H, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":75,"parent":0,"menu_order":70,"comment_status":"closed","ping_status":"closed","template":"page-template1.php","meta":{"footnotes":""},"class_list":["post-231","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/comments?post=231"}],"version-history":[{"count":75,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/231\/revisions"}],"predecessor-version":[{"id":1843,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/pages\/231\/revisions\/1843"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/media\/75"}],"wp:attachment":[{"href":"https:\/\/bms.mimsit.net\/dosing\/wp-json\/wp\/v2\/media?parent=231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}